CAS 480449-70-5|Edoxaban

Taw qhia
Edoxaban yog ib qho me me-molecule qhov ncauj anticoagulant, coagulation factor X (FXa) inhibitor. Thaum lub sij hawm coagulation txheej txheem, activated coagulation factor X (FXa) activates prothrombin (FII) Chemicalbook rau hauv thrombin (FIIa), uas txhawb kev tsim ntawm fibrin, yog li tsim thrombus. phiaj.

Specification ntawm CAS 480449-70-5|Edoxaban

Synthesis ntawmCAS 480449-70-5|Edoxaban

Rau N-(5-chloropiperidin-2-yl)-N'-[(1S,2R,4S)-4-(N,N-dimethylformamido){{10} }(amino) ntawm chav sov Methanesulfonic acid (66 ml) tau ntxiv rau kev ncua ntawm tert-butoxycarbonyl)cyclohexyl]oxamide (95.1 g) hauv acetonitrile (1900 ml), thiab cov sib tov tau nplawm ntawm qhov kub thiab txias rau 2 teev. Nyob rau hauv dej txias txias, rau cov tshuaj tiv thaiv tau ntxiv triethylamine (155 ml), 4,5, Tshuaj Phau Ntawv 6,7-tetrahydro-5-methyl-thiazolo[5,4-c]pyridine{ {27}}carboxylic acid hydrochloride (52.5g), 1-hydroxybenzotriazole (33.0g), 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride (46.8g), stirred ntawm chav tsev kub rau 16 hnu. Triethylamine thiab dej tau ntxiv, thiab tom qab nplawm rau 1 teev nyob rau hauv dej khov-txias, cov muaju tau sau los ntawm kev pom kom tau 103.2 g ntawm edoxaban, cov compound (1).

Cim npe nrov: cas 480449-70-5,480449-70-5,edoxaban, nqe, hais, luv nqi, hauv Tshuag, muag