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CAS: 120068-37-3|5-Amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole{ {9}}carbonitrile
Lub npe:5-Amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H- pyrazole -3-carbonitrile
CAS: 120068-37-3
Purity: 98%
Cov mis mos molecular: C12H4Cl2F6N4OS
Molecular Luj: 437.15
Cov ntsiab lus melting: 203.92 ° C (Predicted)
Boiling Point: 510.1 degree C ntawm 760 mmHg (Predicted)
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Lub npe:5-Amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H- pyrazole -3-carbonitrile
Synonyms: Fipronil; Termidor
CAS: 120068-37-3
Purity: 98%
Molecular Formula: C12H4Cl2F6N4OS
Molecular Luj: 437.15
Cov ntsiab lus melting: 203.92 ° C (Predicted)
Boiling Point: 510.1 degree C ntawm 760 mmHg (Predicted)
EINECS:424-610-5
Ceev: 1.477-1.626g/cm3
Tsos: Tawm dawb hmoov
Solubility: DMF: 20 mg/ml; DMF: PBS (pH 7.2) (1:4): 0.2 mg/ml; DMSO: 14 mg/ml; Ethanol: 10 mg/ml
Dej solubility: 1.9-2.4 mg 1l-1 (20 degree)
pKa: {{0}} 86± 0.20(Tswv Ntuj)
Λmax: 208nm (H2O) (lit.)
IC50:GABA receptor alpha-4 subunit: IC50 = 2.3 nM (tib neeg); GABA receptor beta-3 subunit: IC50 = 28 nM (tib neeg)
Refractive Index: n20D 1.62 (Tshaj tawm)
Cia txias: Khaws ntawm chav tsev kub
InChi:InChI=1S/C12H4Cl2F6N4OS/c13-5-1-4(11(15,16)17)2-6(14)8(5)24-10(22)9(7 (3-21)23-24)26(25)12(18,19)20/h1-2H,22H2
InChi Key:ZOCSXAVNDGMNBV-UHFFFAOYSA-N
Daim ntawv thov: Fipronil(CAS: 120068-37-3)yog ib qho channel blocker uas thaiv GABA-gated chloride channels thiab glutamate-activated chloride channels (GluCls). Hauv Xenopus oocyte kev tshawb fawb fipronil thaiv cov lus teb ntawm GABA receptors. Kev tshawb fawb qhia tias fipronil tuaj yeem nce qib ntawm apoptosis hauv PC-12 hlwb. Kev khi ntawm 4-n-[3H]propyl-4'-ethynylbicycloorthobenzoate ([3H]EBOB) rau GABA-gated chloride ion channel yog inhibited los ntawm fipronil hauv Drosophila melanogaster.
Siv:
1. Hosie, AM, et al. 1995. Nr. J. Pharmacol. 115: 909-912} ib. PIB: 75825199
2. Cole, LM, et al. 1995. Lub Neej Sci. 56: 3 :ua. PIB: 7885191
3. Narahashi, T., et al. 2010. Pestic Biochem Physiol. 97:3 :ua. PIB: 20563240
4. Hu, XF, et al. 2010. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 28: 264-267}. PIB: 20465951
Ntim & Xa
Pob: 500g / 1kg / 5kg / 10kg / bulk pob
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Cim npe nrov: cas:120068-37-3|5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1h-pyrazole{ {9}}carbonitrile, nqe, hais, luv nqi, hauv Tshuag, muag
