CAS: 98-92-0|Nicotinamide

Lub npe: Nicotinamide

Synonyms: Niacinamide; Nicotinic Acid Amide; Pyridine -3-carboxylic acid amide

CAS: 98-92-0

Purity: 99 feem pua

Molecular Formula: C₆H₆N₂O

Molecular Luj: 122.10

Melting Point: 128-131 degree C (lit.)

Boiling Point: 150-160 degree

EINECS:202-713-4

Qhov ceev: 1.4 g / cm3³ntawm 20 degree C

Cov tsos mob: Dawb rau lub teeb daj hmoov

Stability: ruaj khov. Incompatible nrog muaj zog oxidizing neeg sawv cev.

Solubility: Soluble hauv dej (1000 g / l ntawm 20 ° C), ethanol (100 mM), glycerol (1 g / 10ml), DMSO (100 mM), methanol, butanol, chloroform, thiab ether (me ntsis).

pKa: 3.3 (ntawm 20 degree)

Refractive Index: N20D 1.47

IC50:Anandamide amidohydrolase: IC50 = 3.3 µM (rat); NAD-dependent deacetylase sirtuin 2: IC50 = 11 µM (tib neeg); NAD-dependent deacetylase sirtuin 3: IC50 = 14 µM (tib neeg); NAD-dependent deacetylase HST2: IC50 = 91 µM (Saccharomyces cerevisiae S288c)

Cia txias: 2-8 degree

Daim ntawv thov: Nicotinamide(CAS: 98-92-0)yog lub tsev thaiv (tiv thaiv kev tiv thaiv) ntawm coenzymes nicotinamide adenine dinucleotide (NAD) thiab nicotinamide adenine dinucleotide phopshate (NADP). Nws tuaj yeem siv los ua ib qho substrate ntawm nicotinamide phosphoribosyltransferase (NAMPT, EC 2.4.2.12), tus nqi txwv enzyme rau NAD (ntxiv) biosynthesis thiab ib qho tseem ceeb taw qhia molecule. Nws yog ib qho amide derivative ntawm vitamin B3 thiab PARP inhibitor.

Siv:

Kevin J.Bitterman; Rozalyn M.Anderson; Haim Y.Cohen; Magda Latorre-Esteves; David A.Sinclair. Inhibition ntawm silencing thiab ceev kev laus los ntawm nicotinamide, ib tug putative negative regulator ntawm poov xab Sir2 thiab tib neeg SIRT1. Phau ntawv Journal of Biological Chemistry. 2002, 277, (47), 45099-45107

Rozalyn M.Anderson; Kevin J.Bitterman; Jason G. Wood; Oliver Medvedik; David A.Sinclair. Nicotinamide thiab PNC1 tswj lub neej ncua sij hawm los ntawm kev txwv calorie hauv Saccharomyces cerevisiae. Tsab ntawv rau Ntuj. Xyoo 2003, 423, 181-185

Ntim & Xa

Pob: 100g / 250g / 500g / bulk pob

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