CAS 1474110-21-8 GSK-2981278

Lub npe:GSK-2981278

Synonyms:GSK2981278;Ror gama modulator 1;Benzenesulfonamide,N-(4-ethylphenyl)-3-(hydroxymethyl)-N-(2-}methylpropyl)-4-((tetrahydro{{9}) }H-pyran-4-yl)methoxy)-;GSK{13}};

CAS:1474110-21-8

Purity:Ntau dua lossis sib npaug li 98 feem pua

Molecular Formula:C₂₅H₃₅TSIS MUAJ₅S

Molecular Luj:461.61

Melting Point:N/A

Boiling Point:622.6 ± 65. 0 degree (Predicted)

PSA:84.45000

LogP:5.47880

Qhov tsos:Ib tug crystalline khoom

Ceev:1.18 0± 0.06 g / cm3 (Tshaj tawm)

Kev ruaj ntseg:Ntau tshaj lossis sib npaug li 2 xyoos

Solubility:DMF: 30 mg/ml; DMF: PBS (pH 7.2)(1:3): 0.25 mg/ml; DMSO: 5 mg/ml; Ethanol: 15 mg/ml

Acidity coefficient:14.1 0± 0.10 (Tshaj tawm)

Kev cia khoom:(-20 degree)

InChi:InChI=1S/C25H35NO5S/c1-4-20-5-7-23(8-6-20)26(16-19(2)3)32(28,29)24-9-10-25(22({ {15}})17-27)31-18-21-11-13-30-14-12-21/h5-10,15,19,21,27H,4,11-14,16-18H2,{27 }}H3

InChi Key:LZLBRISQTJVZNP-UHFFFAOYSA-N

Daim ntawv thov:GSK 2981278 (GSK2981278) yog lub zog, xaiv ROR /ROR t inhibitor uas muaj zog tiv thaiv IL-17A thiab IL-22 protein secretion hauv tib neeg peripheral T cell nrog IC50 ntawm 3.2 nM.

Siv:

[1]. Smith SH, et al. Kev txhim kho ntawm Kev Kho Mob Psoriasis Targeting ROR : Los Ntawm Lub Rooj Zaum rau Daim tawv nqaij. PLoS Ib. 2016 Feb 12; 11(2):e0147979.

Ntim & Xa

Pob:5g / 10g / 25g / 50g / tej pob

Kev thauj mus los:los ntawm huab cua lossis dej hiav txwv shipping lossis cov neeg siv khoom xav tau.

Delivery Detail:Hauv 3-5 hnub tom qab them tag nrho.

Cov nqe lus them nqi yooj yim:Txhawb T / T, Paypal, Credit Card.

Peb tuaj yeem muab rau koj:

1.Qhov zoo tshaj plaws hauv koj qhov kev xav tau

2.Competitive nqi nyob rau hauv Tuam Tshoj ua lag luam

3.Mature technical support

4.Professional logistic txhawb txhua yam peb xav tau yog kev lag luam yeej-yeej. xa koj cov lus nug rau peb, koj yuav tau txais nws!

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