Kev tshuaj xyuas ntawm Synthesis ntawm 2,3-Dichloro-5-Trifluoromethyl Pyridine

Taw qhia

Tom ntej: CAS 69045-84-7 2,3-Dichloro-5-Trifluoromethyl Pyridineyog ib qho tseem ceeb heev fluorine -muaj pyridine organic intermediate. Nws yog siv nyob rau hauv zus tau tej cov series ntawm high- tshuaj tua kab ua tau zoo xws li diafenthiuron, fenflunom, lub siab -efficiency herbicide fenflufop thiab lub siab -efficiency fungicide fluazinam. Qhov tseem ceeb ntawm cov tshuaj tua kab tshiab

Txheej txheem cej luam ntawm Synthetic Routes

1) Siv 2,3-dichloro-5-trichloromethylpyridine ua raw khoom

106.16 g (0.4 mol) ntawm 2,3-dichloro-5-trichloromethylpyridine thiab 180 g (9 mol) ntawm anhydrous hydrogen fluoride tau ntxiv rau polyethylene reactor, thiab ntsuas kub ntawm -20 degree hauv 3 h Maj mam ntxiv mercuric oxide, tswj cov tshuaj tiv thaiv kub ntawm lub cev kom tsis txhob siab tshaj 35 degree, thiab do cov tshuaj tiv thaiv rau li 22 teev tom qab ntxiv, kom txog thaum lub kaw lus grey-dawb. Lim, neutralize lub filtrate nrog sodium bicarbonate, extract nrog dichloromethane, qhuav nrog anhydrous sodium sulfate, tshem tawm cov dichloromethane nyob rau hauv lub siab txo kom tau cov khoom 2,3-dichloro-5-trifluoromethylpyridine, tus conversion tus nqi yog 100 feem pua, thiab cov selectivity yog 98 feem pua.

2) Siv 3-methylpyridine ua raw khoom

Noj 50 g ntawm 2,3-dichloro-5-trichloromethylpyridine, ntxiv catalyst, kub txog 170 degree, maj mam qhia anhydrous hydrogen fluoride gas, thiab ua rau 11 teev. Tom qab cov tshuaj tiv thaiv tiav, siv 5 feem pua ​​​​sodium bicarbonate tov nyob rau hauv Thiab, cov organic theem tau sib cais, ntxuav nrog dej thiab qhuav kom tau ib tug crude khoom nrog ib tug cov ntsiab lus ntawm 85 feem pua ​​thiab cov tawm los ntawm 65 feem pua.

3) Siv 2-chloro-5-trifluoromethylpyridine ua raw khoom

Noj 363 g ntawm 2-chloro-5-trifluoromethylpyridine, ntxiv 325 g ntawm ferric chloride, dhau cov roj chlorine, kub txog 150-170 degree thiab hnov ​​​​mob rau 18 h, ntxiv cov tshuaj tiv thaiv rau 1.5 L ntawm cov dej kub, cais tawm. roj txheej tau qhuav nrog anhydrous sodium sulfate thiab kho kom tau 163 g ntawm cov khoom.

Qhov chaw

Kev tshuaj xyuas ntawm Synthesis ntawm 2,3-Dichloro-5-trifluoromethyl Pyridine [YUAN Qi-liang, SHEN De-long, LU Xin-xin, Fu Qing]