Kev tsim cov Difluoroacetic Acid

Taw qhia

Difluoroacetic acid feem ntau yog siv los ua tshuaj thiab tshuaj tua kab nruab nrab. Nws tseem tuaj yeem siv los ua cov tshuaj reagent tshiab rau C-H difluoromethylation ntawm heteroaromatic compounds. Nws tseem tuaj yeem siv rau hauv qhuav etching. thiab polysilicon muaj qhov sib txawv siab xaiv, uas tuaj yeem cuam tshuam kev puas tsuaj rau silicon oxide

Txoj kev tsim khoom ntawmTom ntej: Difluoroacetic Acid CAS 381-73-7

1) Siv 2,4,6-tris(difluoromethyl)-s-triazine li raw khoom

Kev sib xyaw ntawm 2,4,6-tris(difluoromethyl)-s-triazine thiab dej yog rhuab nyob rau hauv lub xub ntiag ntawm ib tug catalyst xws li sodium hydroxide, tom qab sib cais ntawm unreacted triazine, lub acidified aqueous theem yog lim, ces muab rho tawm nrog ob peb feem ntawm ether. Difluoroacetic acid tuaj yeem yooj yim tau los ntawm kev faib cov ether qhuav extract

2) Siv dichloroacetic acid ua raw khoom

Cov tshuaj tiv thaiv no yog halogen atom pauv cov tshuaj tiv thaiv. KF (18 g) tau yaj hauv 14 mL dej, tom qab ntawd dichloroacetic acid (2 g) tau ntxiv rau cov kua dej KF saum toj no, qhov kub tau nce mus rau 150 degree, thiab qhov nruab nrab yog nplawm ntawm 150 degree rau 6 min. Tom qab rov qab mus rau chav sov, cov tshuaj aqueous tau tshuaj xyuas los ntawm 1H NMR thiab 19F NMR. Kev hloov pauv ntawm dichloroacetic acid yog 100 feem pua, thiab cov txiaj ntsig ntawm difluoroacetic acid yog 94 feem pua.

3) Kev npaj ntawm difluoroacetic acid los ntawm dichloroacetyl chloride

Nyob rau hauv lub xub ntiag ntawm ib tug chromium-raws li catalyst, dichloroacetyl chloride thiab hydrofluoric acid yog reacted nyob rau hauv cov roj theem los npaj difluoroacetyl fluoride, thiab difluoroacetyl fluoride yog hydrolyzed kom tau difluoroacetic acid