10288-72-9|6-HYDROXY-1, 4-BENZODIOXANE

Taw qhia
6-HYDROXY-1, 4-BENZODIOXANE yog benzodioxans heterocyclic tsev thaiv.

Specification ntawm CAS: 10288-72-9 6-HYDROXY-1, 4-BENZODIOXANE

Synthesis ntawmCAS: 10288-72-9 6-HYDROXY-1, 4-BENZODIOXANE

Cov xwm txheej:

Nrog poov tshuaj fluoride; 3-chloro-benzenecarboperoxoic acid Hauv dichloromethane ntawm 20 degree; Txias nrog dej khov;

Cov txheej txheem sim:

Cov saum toj no (1) (2.7 g, 16 mmol) tau yaj hauv 230 mL ntawm CH2Cl2 thiab txias nrog dej khov. Rau qhov kev daws no, mCPBA (4.2 g, 24 mmol) thiab KF (1.4 g, 24 mmol) tau ntxiv, thiab Cov sib tov yog nplawm nyob rau hauv chav tsev kub thaum hmo ntuj.Cov tshuaj tiv thaiv yog lim nrog n-hexane, thiab cov filtrate yog concentrated nyob rau hauv lub siab txo.Cov residue tau yaj nyob rau hauv MeOH (10 mL), 1N NaOHaq. (5 mL) tau ntxiv, thiab qhov sib tov tau nplawm hauv chav sov thaum hmo ntuj.1N HCl tau ntxiv rau cov tshuaj tiv thaiv, muab rho tawm nrog EtOAc, thiab cov organic txheej tau ntxuav nrog dej thiab saturated saline, qhuav dhau Na2SO4, concentrated nyob rau hauv lub siab txo. , thiab ces concentrated.Cov residue tau purified los ntawm silica gel kem chromatography (n-hexane: EtOAc=3: 1) kom tau cov compound (2) (2.4 g, 98 feem pua ​​).

Siv:

Shimane University; Furuta, Kenjiro; Yamada, Naoko

JP 2020/11914, 2020, A

Cim npe nrov: 10288-72-9,cas 10288-72-9,6-hydroxy-1,4-benzodioxane, nqe, hais, luv nqi, hauv Tshuag, muag