CAS 2353-33-5|5-Aza-2'-deoxy Cytidine

Lub npe:5-Aza-2'-deoxy Cytidine

Synonyms:4-Amino-1-(2-deoxy- -D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H ) - ib; 2-Desoxy-5-azacytidine; 2'-Deoxy-5-azacytidine; DAC; Dacogen; Decitabine; NSC 127716; - Decitabine;

CAS:2353-33-5

Purity:Ntau dua lossis sib npaug li 99 feem pua

Molecular Formula:C₈H₁₂N₄O₄

Molecular Luj:228.21

Melting Point:200 degree (lub kaum hli ntuj)

Boiling Point:485.8ºC ntawm 760 mmHg

Flash Point:247.6ºC

Ceev:1.3771 g/cm³(nrog kwv yees)

Qhov tsos:Dawb rau Off-dawb hmoov

Kev ruaj ntseg:ruaj khov. Tej zaum yuav lub teeb los yog huab cua rhiab heev. Incompatible nrog muaj zog oxidizing neeg sawv cev

Solubility:DMSO (me ntsis), Methanol (me ntsis, rhaub), Dej (me ntsis, Sonicated)

Acidity coefficient:14. {2}}2 ± 0.60

Refractive Index:1.779

Kev cia khoom:Khaws nyob rau hauv qhov tsaus ntuj nti, inert cua, Khaws rau hauv lub freezer, nyob rau hauv -20 degree

Daim ntawv thov:5-Aza-2′-Deoxycytidine yog ib qho Dnmt inhibitor qhia los hloov cov noob caj noob ces. 5-Aza-2′-Deoxycytidine tau tshaj tawm tias ua rau phosphorylation inhibition ntawm 2′-deoxycytidine hauv qee lub hlwb thiab kev koom ua ke ntawm 2′-deoxycytidine rau hauv DNA. Cov kev sim tau pom tias 5-Aza-2'-Deoxycytidine ua rau muaj kev hloov pauv hauv lub xeev sib txawv ntawm cov kab mob nas embryo thiab tseem inhibits methylation ntawm cov tshiab DNA synthesized. DNA methylation tau raug sau tseg tias yog ib qho tseem ceeb hauv kev txiav txim siab apoptotic susceptibility rau histone deacetylase inhibitors, thiab nws kev tiv thaiv los ntawm 5-Aza-2'-Deoxycytidine tuaj yeem ua rau gene silencing thiab transcriptional repression. Lwm cov kev tshawb fawb qhia tias cell raug rau 5-Aza-2'-Deoxycytidine ua rau muaj kev hloov pauv ntawm lub sijhawm rov ua dua, rov ua dua ntawm cov caj ces repressed, thiab decondensation ntawm heterochromatin. Tsis tas li ntawd, 5-Aza-2'-Deoxycytidine qhia lub peev xwm los ntxias histone hyperacetylation hauv murine centromeric heterochromatin thiab tseem cuam tshuam rau intranuclear faib ntawm histone deacetylase. 5-Aza-2′-Deoxycytidine tseem hu ua Decitabine, 5-Aza-CdR, 5-Aza-dC, thiab 2′-Deoxy-5-azacytidine.

Siv:

1. Veselý, J., et al., 1977. Incorporation of a potent antileukemic agent, 5-aza-2′-deoxycytidine, rau hauv DNA ntawm cov hlwb los ntawm leukemic nas. Kev tshawb nrhiav mob qog noj ntshav. 37(10): 3684-9. PIB: 71199

2. Jones, P A., et al., 1980. Cellular differentiation, cytidine analogs thiab DNA methylation. Cell. 20(1): 85-93. PIB: 6156004

3. Zhu, W G., et al., 2001. DNA methyltransferase inhibition txhim kho apoptosis induced los ntawm histone deacetylase inhibitors. Kev tshawb nrhiav mob qog noj ntshav. 61(4): 1327-33. PIB: 112454299

4. Takebayashi, S., et al., 2001. 5-Aza-2′-deoxycytidine induces histone hyperacetylation ntawm nas centromeric heterochromatin los ntawm ib qho kev ywj pheej ntawm DNA demethylation. Kev sib txuas lus biochemical thiab kev tshawb fawb biophysical. 288(4): 921-6}. PIB: 116889977

Ntim & Xa

Pob:5g / 10g / 25g / 50g / tej pob

Kev thauj mus los:los ntawm FeDex lossis los ntawm hiav txwv shipping lossis cov neeg siv khoom xav tau

Delivery Detail:Hauv 3-5 hnub tom qab them tag nrho.

Cov nqe lus them nqi yooj yim:Txhawb T / T, Paypal, Credit Card.

Cim npe nrov: cas 2353-33-5|5-aza-2'-deoxy cytidine, nqe, hais, luv nqi, hauv Tshuag, muag