Qhov xwm txheej tam sim no Ntawm Cov Tshuaj Siv Tshuaj Intermediates
Dec 14, 2021
Tam sim no, kuv lub teb chaws xav tau ntau dua 2,000 cov khoom siv raw thiab cov khoom nruab nrab rau kev lag luam tshuaj txhua xyoo, thiab qhov kev thov ntau dua 2.5 lab tons. Tom qab ntau tshaj 30 xyoo ntawm txoj kev loj hlob, cov tshuaj raw cov ntaub ntawv thiab intermediates uas yuav tsum tau rau kuv lub teb chaws cov tshuaj ntau lawm yeej yuav tsum matched, thiab tsuas yog ib feem me me ntawm nws yuav tsum tau imported. Ntxiv mus, vim kuv lub teb chaws cov peev txheej ntau thiab cov khoom siv qis, cov khoom nruab nrab tau raug xa tawm ntau ntau. Yog li, dab tsi txoj hauv kev txhim kho kuv lub teb chaws ntsib hauv kev lag luam tshuaj intermediates?
Tom qab ze li ntawm 50 xyoo ntawm kev loj hlob ntawm -lactam tshuaj tua kab mob nyob rau hauv Tuam Tshoj, ib tug tiav lawm system tau tsim. Tam sim no, yuav luag tag nrho -lactam tshuaj tua kab mob (tshwj tsis yog cov ntau yam nyob rau hauv lub sij hawm patent) tuaj yeem tsim hauv kuv lub teb chaws, thiab tus nqi qis heev. Cov zis ntawm penicillin nyob rau hauv lub ntiaj teb no, thiab ib tug loj tus naj npawb ntawm lawv raug xa mus rau lub thoob ntiaj teb ua lag luam; cephalosporin tshuaj tua kab mob yog qhov pib ntawm tus kheej - txaus. Kuj tseem siv zog rau ib feem ntawm kev xa tawm.
Tam sim no, txhua tus neeg nruab nrab txhawb nqa -lactam tshuaj tua kab mob tuaj yeem tsim tawm hauv kuv lub tebchaws. Tsuas yog rau ib nrab - cov tshuaj tua kab mob hluavtaws, 7-ACA thiab 7-ADCA, uas yuav tsum tau raug xa tawm ib nrab, tag nrho cov saw hlau intermediates tuaj yeem tsim tawm, thiab tawm ntau ntau.
Noj phenylacetic acid, lub ntsiab txhawb nruab nrab ntawm -lactam tshuaj tua kab mob, ua piv txwv, muaj ze li ntawm 30 phenylacetic acid manufacturers nyob rau hauv kuv lub teb chaws, nrog rau tag nrho ib xyoos twg muaj peev xwm tsim tau txog 20,000 tons. Txawm li cas los xij, feem ntau cov tuam txhab lag luam me me, nrog cov khoom lag luam loj tshaj plaws ntawm 2, 000 tons, thiab lwm yam loj - nplai ntau lawm ntau pua tons. Hauv xyoo 2003, tag nrho cov kev thov hauv tsev rau phenylacetic acid yog kwv yees li 14, 000 tons, thiab cov qauv siv tau raws li hauv qab no: Penicillin G suav txog 85 feem pua, lwm cov tshuaj suav txog 4 feem pua, cov txuj lom suav txog 7 feem pua, thiab tshuaj tua kab thiab lwm yam teb suav txog 4 feem pua.
Nrog rau kev tsim cov tshuaj tsw qab, tshuaj, tshuaj tua kab thiab lwm yam kev lag luam, qhov kev thov rau phenylacetic acid yuav nce ntxiv. Nws kwv yees tias los ntawm 2005, kuv lub teb chaws kev lag luam kws tshuaj yuav haus txog 14,000 tons ntawm phenylacetic acid, kev lag luam tshuaj tua kab yuav haus 500 tons, thiab kev lag luam naj hoom yuav siv li 2,000 tons. Ua ke nrog kev noj hauv lwm qhov chaw, nws kwv yees tias tag nrho cov kev thov hauv tsev rau phenylacetic acid hauv xyoo 2005 yuav ncav cuag 18,000 tons.
Nyob rau hauv qhov tseeb, cov synthesis ntawm cov tshuaj kuj belongs rau cov tshuaj, tab sis nws yog nruj me ntsis raws li cov kev cai ntawm cov tshuaj cov nroj tsuag, yog li cov chaw tsim tshuaj yuav tsum tau GMP ntawv pov thawj, thiab tshuaj intermediates tshuaj yog raw cov ntaub ntawv rau tshuaj synthesis, tsis yog tshuaj, yog li kuj muaj. hais lus, qhov yuav tsum tau qis dua cov tshuaj. Lub chaw tsim khoom tsis tas yuav muaj ntawv pov thawj GMP tshuaj
