CAS 945667-22-1|Saxagliptin
Cov mis mos molecular: C18H27N3O3
Molecular Luj: 333.43
EINECS: 641-082-3
Purity: 97% Min.
Pob: 1 g / 5 g / 25 g / 100 g / 1 kg
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Khoom Taw qhia
Taw qhia
Saxagliptin yog ib qho kev xaiv thiab thim rov qab DPP4 inhibitor nrog IC50 ntawm 26 nM.
Kev tshawb fawb hauv vitro
Hauv vitro, saxagliptin inhibited FBS, insulin, thiab IGF-1-induced ERK phosphorylation thiab cell proliferation hauv MSCs thiab MC3T3E1 preosteoblasts. Nyob rau hauv qhov tsis muaj kev loj hlob, saxagliptin tsis muaj kev cuam tshuam rau ERK activation ntawm Chemicalbook lossis cell proliferation. Hauv MSC thiab MC3T3E1 hlwb, nyob rau hauv lub xub ntiag ntawm FBS, saxagliptin inhibited Runx2 thiab osteocalcin qhia, collagen I ntau lawm, thiab mineralization, thiab nce PPAR-gamma qhia.
Hauv vivo kev tshawb fawb
Saxagliptin muaj cov txiaj ntsig ncaj qha rau ntawm phab ntsa hlab ntsha los ntawm kev ua kom tsis muaj kev siv thiab txhim kho cov tshuaj tiv thaiv kab mob hauv cov tsiaj ua qauv ntawm hom 2 mob ntshav qab zib. Saxagliptin thim rov qab vascular hypertrophy los ntawm abrogating NAD(P)H oxidase-tsav uncoupling ntawm eNOS thiab txo COX-1- tau txais vasoconstrictor kev ua ub no tshuaj (kev ua ntawm vasoconstrictors los txo qis kev qhia ntawm thromboxane prostaglandin receptors) cov ntshav tsis zoo thiab txhim kho cov ntshav tsis muaj zog. cov hlab ntsha hauv db/db nas. Saxagliptin inhibits DPP-4 thiab tuaj yeem txhim kho islet -cell muaj nuj nqi thiab txo qis glucagon concentrations hauv postprandial thiab yoo mov.
Cim npe nrov: cas 945667-22-1,945667-22-1, saxagliptin, nqe, hais, luv nqi, hauv Tshuag, muag
