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CAS: 4291-63-8 Cladribine

CAS Nr.: 4291-63-8
Cov roj formula: C10H12ClN5O3
Molecular Luj: 285.68700
Purity: 97% Min.
Pob: 5g / 25g / 100g
Lub Sijhawm Lead: Hauv Tshuag
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Khoom Taw qhia

Taw qhia
Nws yog qhov hloov pauv purine nucleoside nrog kev ua haujlwm antileukemic. Cladribine yog ib qho adenosine deaminase inhibitor siv los kho cov plaub hau cell leukemia thiab ntau yam sclerosis. Lub Hom Phiaj: Adenosine DeaminaseCladribine muaj cov concentration-dependent apoptosis-inducing peev xwm hauv HSB2 hlwb. Cladribine inhibits kev loj hlob ntawm thawj mast cell (MC) thiab MC kab HMC-1 nyob rau hauv ib koob tshuaj, nrog qis IC50 qhov tseem ceeb sau tseg hauv HMC-1.2 hlwb harboring KIT D816V piv rau HMC-1.1 hlwb tsis muaj KIT D816V. Cladribine (0. muaj peev xwm biomarkers ntawm kev noj qab haus huv plawv. Diltiazem nce RBC ATP concentrations, uas yog inhibited los ntawm kev txhaj tshuaj ntawm cladribine.

Specification ntawm CAS: 4291-63-8 Cladribine

Yam khoom	SPECIFICATION
Melting point	181-185 degree (lit.)
InChIKey	PTOAARAWEBMLNO-HSUXUTPPSA-N
alpha	D25 -18.8 degree (c=1 hauv DMF)
solubility	Me ntsis soluble hauv dej, soluble hauv dimethyl sulfoxide, me ntsis soluble hauv methanol, xyaum insoluble hauv acetonitrile. Nws qhia txog polymorphism (5.9).
Merck	14,2337
daim ntawv	Dawb khoom
lw max	265nm (EtOH aq.) (lit.)
ceev	2. 03 ± 0.1 g/cm3
Kev ruaj ntseg	Khaws rau hauv lub Freezer
Boiling point	547.6 ± 6 0.0 degree
pka ua	13.75±0.60
CAS DataBase Reference	4291-63-8(CAS DataBase Reference)
cia temp.	-20 degree