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CAS: 144481-98-1 Landiolol Hydrochloride

CAS: 144481-98-1 Landiolol Hydrochloride

Lub npe: Landiolol hydrochloride
CAS: 144481-98-1
Purity: 98 feem pua
Cov mis mos molecular: C25H40ClN3O8
Molecular Luj: 546.05300
Melting Point: 122-127ºC
Boiling Point: 727.5ºC ntawm 760mmHg
Flash Point: 393.8ºC

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Lub npe:Landiolol hydrochloride	CAS:144481-98-1
Purity:98 feem pua	Molecular Formula:C₂₅H₄₀ClN₃O₈
Molecular Luj:546.05300	Melting Point:122-127ºC
Boiling Point:727.5ºC ntawm 760 mmHg	Flash Point:393.8ºC
PSA:127.82000	LogP:2.37760
Qhov tsos:Dawb crystalline hmoov	Ceev:1.201g / cm3
Solubility:Methanol (zoo soluble hauv); Dimethylformamide (soluble hauv); Ethanol (me ntsis sol.in)	Dej solubility:Soluble tag
Vapor Pressure:3.24E -22mmHg ntawm 25 degree	Kev cia khoom:Khaws lub sijhawm ntev ntawm 2-8 degree

Daim ntawv thov:Landiolol hydrochloride (ONO-1101) yog ib qho cardioselective heev, luv-acting adrenergic 1- xaiv antagonist (blocker). Landiolol txo lub plawv dhia los ntawm kev xaiv thaiv 1 receptors nyob rau hauv lub plawv. Nws tau tshaj tawm tias landiolol muaj 8-fold ntau dua cardioselectivity dua esmolol [E1106] hauv vitro. Landiolol yog ib tus neeg ua haujlwm luv luv vim tias pawg ester ntawm landiolol yog hydrolyzed sai heev rau cov metabolite tsis ua haujlwm los ntawm esterases hauv ntshav thiab daim siab. Landiolol hydrochloride yog siv rau kev kho mob ntawm tachyarrhythmia thiab kev tswj kom zoo ntawm lub plawv dhia hauv kev phais. (Cov khoom no yog rau kev tshawb nrhiav nkaus xwb.)

Siv:

S. Iguchi, H. Iwamura, M. Nishizaki, A. Hayashi, K. Senokuchi, K. Kobayashi, K. Sakaki, K. Hachiya, Y. Ichioka, M. Kawamura, Chem. Pharm. Bull. Xyoo 1992, 40, 1462.

A. Sugiyama, A. Takahara, K. Hashimoto, J. Cardiovasc. Pharmacol. Xyoo 1999, 34, 70.

GL Plosker, Tshuaj 2013, 73, 959.

M. Suno, T. Kunisawa, A. Yamagishi, T. Ono, J. Yamamoto, T. Yamada, Y. Tasaki, K. Shimizu, H. Iwasaki, K. Matsubar, J. Chromatogr. Xyoo 2009, 877, 1705.

Y. Hashimoto, S. Nago, M. Tsunekawa, K. Shibakawa, Y. Miyata, Biol. Pharm. Bull. Xyoo 2009, 32, 121.

Ntim & Xa

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