CAS: 129-56-6|TIAB SA 600125

Lub npe: SP600125

Synonyms: JNK Inhibitor II; Anthra(1,9-cd)pyrazol-6(2H)-ib;1,9-Pyrazoloanthrone

CAS: 129-56-6

Purity: 97 feem pua

Molecular Formula: C₁₄H₈N₂O

Molecular Luj: 220.23

Melting Point: 283 ° C

Boiling Point: 489.3 degree C ntawm 760 mmHg (Tshaj tawm)

Qhov ceev: 1.463 g / cm3³ 

Cov tsos mob: yellowish txiv kab ntxwv khoom

Solubility: Soluble hauv dej (ib nrab), DMSO (100 mM), ethanol (5 mM), thiab methanol

pKa: 11.75 (Predicted)

IC50 :JNK1: IC50 = 40 nM; JNK2: IC50 = 40 nM; JNK3: IC50 = 90 nM; PKR: IC 50 = 8 µM (tib neeg)

Refractive Index: 1.80 (Tshaj tawm)

Cia txias: Khaws ntawm chav tsev kub

InChIKey: ACPOUJIDANTYHO-UHFFFAOYSA-N

Daim ntawv thov: SP 600125(CAS: 129-56-6)yog lub zog, xaiv thiab thim rov qab inhibitor ntawm peb JNK enzymes (c-Jun N-terminal kinases), nrog IC50 = 40 nM rau JNK1 thiab JNK2, thiab 90 nM rau JNK3. Inhibition yog kev sib tw nrog rau ATP, thiab tshaj 300-fold ntau xaiv rau JNK piv rau ERK1 thiab p38-2 MAP kinases. SP600125 tau pom tias ua rau muaj kev cuam tshuam ntawm koob tshuaj ntawm phosphorylation ntawm c-Jun, thiab yog li kev qhia ntawm cov noob caj noob ces COX-2, IFN-, IL-2, TNF- , thiab thaiv kev ua kom muaj zog thiab kev sib txawv ntawm thawj tib neeg CD4 cell kab lis kev cai. SP 600125 kuj tau pom tias tiv thaiv apoptosis nyob rau hauv ib qho array ntawm cell hom, thiab inhibit autophagy hauv HeLa hlwb.

Siv:

1. Bennett, BL, et al. 2001. Proc. Natl. Acad. Sci. USA 98: 13681-13686. PIB: 117174299

2. Han, Z., et al. 2001. J. Clin. Kev nqis peev. 108: 73-81} ib. PIB: 114354599

3. Wang W., et al. 2004. Neurosci. Res. 48: 3: XIV. PIB: 14741394

4. Kim, YS, et al. 2008. J Immunol. 181: 3: XIV. PIB: 18941206

Ntim & Xa

Pob: 5g / 10g / 25g / 50g / bulk pob

Kev Thauj Mus Los: los ntawm FeDex lossis los ntawm hiav txwv shipping lossis cov neeg siv khoom xav tau

Kev Qhia Txog Tus Me Nyuam: Hauv 3-5 hnub tom qab them tag nrho

Cov nqe lus them nqi yooj yim: txhawb T / T, Paypal, Credit Card

Cim npe nrov: cas:129-56-6|sp 600125, nqe, hais, luv nqi, hauv Tshuag, kev muag khoom