CAS 57103-68-1|Maytansinol
Cov mis mos molecular: C28H37ClN2O8
Molecular Luj: 565.05
Purity: 97% Min.
Pob: 1 g / 5 g / 25 g / 100 g / 1 kg / 25 kg
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Khoom Taw qhia
Taw qhia
Maytansinol yog cov niam txiv feem ntau ntawm Maytansinoids, uas yog esters ntawm yav dhau los, thiab feem ntau qhia txog kev tiv thaiv kab mob. Maytansinol tau txais ntau ntau los ntawm Japanese kws tshawb fawb los ntawm fermentation thiab hloov mus rau hauv maytansinoids. Maytan Chemicalbook cov tshuaj thiab lawv cov derivatives muaj zog heev inhibitors ntawm microtubule sib dhos. Lawv tuaj yeem ua rau muaj kev cuam tshuam los tiv thaiv mitotic ntawm qib sub-nanomolar, thiab lawv cov ED50 (cov koob tshuaj zoo) yog 10-5 ~ 10-4ug/mL. yog ib qho tshuaj anticancer zoo tagnrho.
Specification ntawm CAS 57103-68-1|Maytansinol
Yam khoom | SPECIFICATION |
pka ua | 9.89 |
Melting point | 205-207 degree |
Qhov ntom | 1.34 g / cm3 |
Cia temp. | Muab kaw rau hauv qhuav, 2-8 degree |
Boiling point | 8 35,8d |
Synthesis ntawmCAS 57103-68-1|Maytansinol
Cov xwm txheej
Nrog lithium (hydro)trimethoxyaluminate Hauv tetrahydrofuran ntawm -40 degree ;
Kev siv
Porter, John; Ding, Yao; Hale, Sarah JM; Perrins, Richard D.; Robinson, Angela; Mazanetz, Michael P.; Wu, Yubo; Ma, Yinping; Conlon, Kelly; Coulter, Tom
[Bioorganic and Medicinal Chemistry Letters, 2020, vol. 30, nr 24, art. tsis muaj. 127634] ib.
Cim npe nrov: cas 57103-68-1|maytansinol, nqe, hais, luv nqi, hauv Tshuag, kev muag khoom
