CAS 139504-50-0|N2'-deacetyl-N2'-(3-Mercapto-1-}oxopropyl)-Maytansine
Cov mis mos molecular: C35H48ClN3O10S
Molecular Luj: 738.29
Purity: 97% Min.
Pob: 1 g / 5 g / 25 g / 100 g / 1 kg / 25 kg
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Khoom Taw qhia
Taw qhia
Maytansine DM1 yog tubulin inhibitor uas khi ntawm qhov kawg ntawm microtubules thiab inhibits microtubule dynamics. Maytansine yog ib qho tshuaj tiv thaiv kab mob-conjugable maytansinoid siv los kov yeej maytansine-txog kab mob toxicity thiab txhim kho qog nqaij hlav.
Specification ntawm CAS 139504-50-0|N2'-deacetyl-N2'-(3-Mercapto-1-}oxopropyl)-Maytansine
Yam khoom | SPECIFICATION |
pka ua | 9.82 |
Melting point | 190-192 degree (decomposition) |
Qhov ntom | 1.33g / cm3 |
Cia temp. | Muab kaw rau hauv qhuav, 2-8 degree |
Boiling point | 9 37,1d |
Synthesis ntawmCAS 139504-50-0|N2'-deacetyl-N2'-(3-Mercapto-1-}oxopropyl)-Maytansine
Cov xwm txheej
Nrog ethylenediaminetetraacetic acid; diothiothreitol hauv methanol; phosphate tsis muaj; ethyl acetate rau 3h; pH =7.5;
Kev siv
Widdison, Wayne C.; Wilhelm, Sharon D.; Cavanagh, Emily E.; Whiteman, Kathleen R.; Leece, Barbara A.; Kovtun, Yelena; Goldmacher, Victor S.; (…) Blättler, Walter A.; Chari, Ravi VJ
[Journal of Medicinal Chemistry, 2006, vol. 49, nr 14, p. 4392 - 4408]
Cim npe nrov: cas 139504-50-0|n2'-deacetyl-n2'-(3-mercapto-1-oxopropyl)-maytansine, nqe, hais, luv nqi, hauv Tshuag, kev muag
