Dab tsi yog qhov cuam tshuam ntawm Licochalcone A?

Licochalcone, tseem hu uaLicochalcone A(CAS 58749-22-7), feem ntau pom muaj nyob rau hauv legumes licorice, licorice glabra thiab licorice inflated. Kev tshawb fawb niaj hnub no qhia tau hais tias licorice chalcone A muajAnti-aging,Anti-inflammatory, Anti-tumor, Anti-microbial, Anti-HIV, Anti-allergic thiab lwm yam teebmeem, thiab nws kuj yog siv los ua raw khoom rau cov synthesis ntawm lwm yam active derivatives.

Anti-aging:

Hauv kev tshawb fawb coj los ntawm pawg tshawb fawb los ntawm Tuam Tshoj, lawv tshawb xyuas seb LA puas muaj kev tiv thaiv kev laus hauv adipose-derived qia hlwb (ADSCs). Lawv tau ua β-galactosidase staining thiab ntsuas cov pa oxygen reactive, txheeb ze telomere lengths, thiab P16ink4a mRNA qhia. Osteogenesis tau soj ntsuam los ntawm Alizarin Liab staining thiab adipogenesis los ntawm kev soj ntsuam Roj Liab O staining. Protein qib ntawm cov cim qhia muaj feem cuam tshuam txog kev hloov pauv cuam tshuam 2 thiab lipoprotein lipase kuj tau kuaj xyuas. RNA sequencing thiab ntsuas ntawm glycolysis kev ua ub no tau pom tias LA ua kom muaj glycolysis hauv ADSCs. Ua ke, cov ntaub ntawv qhia tau hais tias LA muaj kev tiv thaiv kev laus los ntawm kev qhib txoj hauv kev glycolysis.

Anti-plasmodium:

Plasmodium yog ib pawg ntawm cov kab mob uas ua rau tib neeg noj qab haus huv. Ntawm lawv, malaria tshwm sim los ntawm Plasmodium falciparum yog hu ua falciparum malaria. Cov tsos mob ntawm falciparum malaria yog qhov mob hnyav tshaj plaws, thiab nws tus kab mob kis thiab tus neeg tuag kuj yog thawj zaug ntawm txhua yam kab mob malaria. Nyob rau hauv xyoo tas los no, qhov nce sai ntawm cov neeg nyob hauv av ntab, ua ke nrog kev xa mus tas li ntawm cov chaw txawv teb chaws ntawm kev kis tus kab mob, tau ua rau muaj qhov tshwm sim thiab qhov xwm txheej ntawm kev ua phem phem txuas ntxiv mus ntxiv. Nyob rau hauv Asia thiab Africa, malaria tseem yog ib qho ntawm cov kab mob loj tshaj plaws uas ua rau muaj kev phom sij rau tib neeg' kev noj qab haus huv.

IC50 ntawm licorice chalcone A tiv thaiv Plasmodium falciparum yog 1.43mg·L-1, uas tuaj yeem cuam tshuam Plasmodium falciparum mitochondrial panthenol-cytochrome C reductase thiab ua pa chain complex II (succinic acid-pan Quinone reductase) kev ua haujlwm, qhia tias nws cov haujlwm tiv thaiv malarial. tej zaum yuav muaj feem xyuam rau inhibition ntawm mitochondrial respiratory saw ntawm Plasmodium, thiab nws daim ntawv thov ua ke nrog artemisinin tuaj yeem txhim kho cov kev tiv thaiv malarial ntawm artemisinin. Licorice chalcone A yog cov muaj zog daim nyias nyias active neeg sawv cev, uas muaj peev xwm hloov cov qe ntshav liab ib txwm mus rau hauv acanthocytes, yog li inhibiting kev loj hlob ntawm Plasmodium falciparum. Cov txiaj ntsig ntawm synchronous nyob rau hauv vitro kab lis kev cai thwmsim qhia tau hais tias nws inhibitory mechanism yog tsuas yog inhibit invasion. Kev txhaj tshuaj rau cov nas Qhov kev hloov pauv ntawm cov qe ntshav liab tuaj yeem pom hauv licorice chalcone A.

Siv:

Licochalcone Kev ua kom glycolysis txoj hauv kev muaj kev tiv thaiv kev laus ntawm tib neeg adipose qia hlwb

Ying Wu, Hao Wang, Jianbo Zhu, Haitao Shen, Hailiang Liu

Tau qhov twg los: https://www.aging-us.com/article/203734/text