Formulating nrog CPC: Them, pH, thiab cov khoom xyaw uas noj koj cov Active

Tus qauv hais tias0.1% cetylpyridinium chloride. COA hais ntau dua lossis sib npaug rau 99% purity. Tso cov ntawv xeem. Rau lub hlis tom qab, tus neeg siv khoom xa rov qab cov tshuaj ntxuav qhov ncauj thiab nug vim li cas nws tsis ua haujlwm. Daim ntawv lo tsis tau hloov. CPC tsis tau degraded. Ib yam dab tsi hauv cov mis tau ntsiag to noj nws txij li hnub ib.

Kab lus no yog hais txog qhov ntawd. Feem ntau cov formulator paubCetylpyridinium Chloride (CAS 123-03-5)yog cationic antiseptic. Tsawg dua paub tias lub qhov rais nqaim li cas ntawm "tam sim no" thiab "ua tau tiag tiag." Qhov txawv feem ntau tsis yog CPC nws tus kheej. Nws yog tus nqi ib puag ncig nws, pH nws zaum hauv, thiab cov khoom ntxiv uas khi rau nws ua ntej nws puas tau mus txog cov kab mob. Alfa Chemical tsimCAS Nr .: 123-03-5nyob rau hauv Zhengzhou, Tuam Tshoj rau kev kho qhov ncauj formulators thoob ntiaj teb.

Qhov teeb meem Cationic

CPC cov tshuaj tiv thaiv kab mob pib nrog electrostatics. Cov molecule muaj ib qho txiaj ntsig zoo rau nws cov pyridinium nitrogen. Cov kab mob ntawm tes muaj qhov tsis zoo los ntawm teichoic acids, lipopolysaccharides, thiab daim nyias nyias phospholipids. CPC cation adsorbs rau ntawm qhov chaw, ntxig nws cov saw cetyl mus rau hauv cov lipid bilayer, thiab cuam tshuam cov membrane kev ncaj ncees. Lub cell xau. Nws tuag.

Qhov no mechanism yog ceev. A50 mg/100 mL CPC tov- cov concentration siv hauv cov tshuaj qhov ncauj ua lag luam - sterilizes tag nrho cov kab mob hauv qhov ncauj uas tau kuaj hauv ib feeb. Ntawm3 mg/100 mL, xya ntawm kaum hom kab mob raug tua tsis pub dhau peb feeb. Qhov kev ua si tsis yog marginal. Thaum CPC ua haujlwm, nws ua haujlwm sai.

Qhov teeb meem yog tias yuav luag txhua lwm cov khoom xyaw hauv cov tshuaj txhuam hniav lossis tshuaj ntxuav qhov ncauj yog sib tw rau tib qhov chaw sib txuas electrostatic. Anionic surfactants, anionic thickeners, phosphate ntsev, thiab qee cov abrasives tag nrho cov nqi tsis zoo. CPC tsis paub qhov txawv ntawm cov kab mob kab mob thiab cov kab mob sulfate. Nws khi rau txhua yam uas tsis zoo them thiab muaj. Thaum muab khi rau ib qho khoom noj khoom haus, nws tsis muaj rau kev siv tshuaj tua kab mob.

SLS thiab Insoluble Complex

Sodium lauryl sulfate (SLS)yog cov surfactant feem ntau hauv cov tshuaj txhuam hniav. Thaum CPC thiab SLS sib tov nyob rau hauv ib theem aqueous, lawv tsim ib qho complex insoluble. Lub complex tsis yog me ntsis poob. Hauv cov tshuaj txhuam hniav uas muaj1-2% SLS, feem ntau ntawm CPC tuaj yeem ua rau tsis muaj zog hauv cov sij hawm sib xyaw.

Lub mechanism yog ncaj nraim. SLS yog ib qho anionic surfactant nrog sulfate headgroup. CPC yog ib qho cationic surfactant nrog pyridinium headgroup. Cov tshuaj tiv thaiv surfactants nyob rau hauv dej ua dab tsi oppositely them surfactants ua: lawv koom, tsim ion khub, thiab precipitate tawm ntawm kev daws. Lub precipitate tseem nyob rau hauv lub raj. Nws tsuas yog tsis nyob hauv cov qaub ncaug.

Yog tias koj tab tom tsim cov tshuaj txhuam hniav CPC thiab koj qhov system surfactant yog SLS-raws li, qhov kev thov tshuaj tiv thaiv kab mob raug cuam tshuam txawm tias CPC concentration ntawm daim ntawv lo. Tsuas yog txhim khu kev qha fixes yog:

• Hloov SLS nrog qhov tsis yog -ionic surfactant. Poloxamer 407, PEG-40 hydrogenated castor roj, thiabpolysorbate 20feem ntau siv nrog CPC yam tsis muaj kev poob haujlwm. Cov surfactants no tsis muaj nqi them thiab tsis sib tw rau CPC qhov chaw khi.
• Siv cov amphoteric surfactant ua thawj. Cocamidopropyl betaine hmoovnqa ob qho tib si zoo thiab tsis zoo tab sis coj raws li zwitterion ntawm cov qauv tsim pH. Nws yog sib xws nrog CPC ntawm cov qib siv tswv yim.
• Yog tias SLS tsis yog - sib tham tau rau tus nqi lossis ua npuas ncauj,lees tias CPC yuav ua tsis tau zoo. Encapsulation mus kom ze muaj tab sis ntxiv kev ua haujlwm nyuaj thiab tus nqi uas tsis tshua muaj cwj mem tawm rau cov khoom siv kho qhov ncauj.

Tib lub logic siv rau anionic thickeners.Sodium carboxymethylcellulose (CMC)thiabcarbomerkhi CPC los ntawm lawv pawg carboxylate.Xanthan cov pos hniav, thaum tsawg anionic, tseem tuaj yeem cuam tshuam nyob ntawm pH thiab concentration. Tsis yog -ionic thickeners -hydroxyethyl cellulose, Hydroxypropyl methylcellulose yog ib qho khoom siv zoo, los yog hloov pauv starches - zam qhov teeb meem nkaus.

Silica, Calcium Carbonate, thiab Abrasive Question

Abrasives tseem ceeb tshaj li feem ntau cov neeg tsim khoom xav tau. Qee qib ntawmhydrated silicathiabcalcium carbonateadsorb CPC mus rau lawv qhov chaw particle, txo tus nqi ntawm cov dawb active nyob rau hauv lub aqueous theem.

Qhov no tsis yog ib qho teeb meem sib xws. Cov tuam txhab lag luam Silica tau tsim cov qib nrog cov kev kho saum npoo uas txo qis CPC khi. Precipitated silicas nrog kev hloov kho saum npoo tuaj yeem ua tiavCPC compatibility tus nqi siab dua 85-90%, lub ntsiab lus feem ntau ntawm CPC tseem nyob dawb hauv kev daws teeb meem. Standard silica qib yam tsis muaj kev hloov kho yuav khi ib feem loj dua.

Calcium carbonate-raws li abrasives yog ib qho nyuaj dua. Lawv zoo li thawb kev tsim pH saum toj 8, uas yog sab nraum CPC lub qhov rais ruaj khov, thiab lawv cov chemistry saum npoo yog ntau reactive rau hom cationic. Yog tias CPC yog thawj cov tshuaj tua kab mob ua haujlwm, silica-raws li abrasive system yuav luag txhua qhov kev xaiv zoo dua.

pH: Ob qho kev txwv, ib lub qhov rais

CPC qhov muaj txiaj ntsig pH ntau yog nqaim vim tias kev ruaj ntseg thiab kev ua haujlwm rub tawm ntawm qhov sib txawv.

Hauv qab nopH 5.0, cov tshuaj tiv thaiv kab mob ntawm CPC poob qis. Cov txheej txheem tsis nkag siab tag nrho, tab sis qhov kev soj ntsuam ua tau zoo ib yam: acidic tej yam kev mob txo tus nqi thiab cov kab mob tua kab mob.

Saum toj nopH ntawm 8.0, CPC solubility poob thiab nag lossis daus yuav nce. Ntawm pH siab, pyridinium cation tuaj yeem ua rau nruab nrab los ntawm hydroxide, tsim cov hauv paus dawb, uas yog dej tsis zoo -soluble. Thaum CPC precipitates, nws yog functionally ploj mus.

Qhov zoo tshaj qhov rais yogpH 5.5-7.5. Rau qhov ncauj qhov ncauj formulations, acitrate lossis phosphate tsis nyob ntawm pH 6.0-6.5yog tus qauv kev coj ua. Phosphate buffers muaj qhov zoo ntxiv: lawv tsis qhia ntau yam anions uas tuaj yeem cuam tshuam nrog CPC. Monovalent acid systems - phosphoric acid los yog hydrochloric acid rau kev hloov pH - yog nyiam tshaj cov kua qaub ntau yam xws li citric acid lossis EDTA, uas tuaj yeem chelate lossis khi hom cationic.

Rau cov tshuaj txhuam hniav, pH feem ntau raug txiav txim los ntawm lub tshuab abrasive. Silica-raws li abrasives tso cai rau pH nruab nrab. Calcium carbonate yuam alkaline pH. Yog tias cov qauv tsim kom muaj calcium carbonate rau cov nqi lossis kev ntxhib los mos, CPC yog cov tshuaj tua kab mob tsis raug rau cov kab ke ntawd.

Zinc: Ib Co-Active That Help

Feem ntau cov co-actives tsis ua dab tsi rau CPC lossis cuam tshuam nrog nws.Zincyog qhov kev zam.

Zinc ntsev -zinc chloride, zinc lactate, zinc citrate- ua haujlwm los ntawm kev sib txawv ntawm CPC. Zinc ions inhibit cov kab mob loj hlob thiab ncaj qha neutralizeVolatile sulfur compounds (VSCs), thawj qhov ua rau qhov ncauj malodor. CPC tua cov kab mob thiab txo VSC kev tsim tawm ncaj qha los ntawm kev txo cov kab mob hauv cov neeg. Thaum sib xyaw ua ke, ob lub actives hais txog halitosis los ntawm kev sib ntxiv.

Kev sib koom ua ke tau sau tseg hauv vitro. Tawm tsamAggregatibacteria actinomycetemcomitans, ib qho tseem ceeb ntawm cov kab mob pathogen thiab VSC cov neeg tsim khoom, kev sib xyaw ntawm CPC thiab ZnCl₂ tau pom muaj kev sib koom ua ke inhibition - cov txiaj ntsig tau ntau dua li cov txiaj ntsig ntawm tus kheej cov dej num. Clinically, cov tshuaj yaug qhov ncauj uas muaj CPC thiab zinc lactate tau pom tias muaj kev tiv thaiv -malodor kev ua tau zoo uas ntau tshaj qhov uas ib leeg xa tawm.

Kev sib raug zoo caveat: zinc ntsev yog cationic. Lawv tsis sib tw nrog CPC rau qhov chaw anionic binding raws li SLS ua. Ob leeg tuaj yeem koom ua ke hauv tib lub sijhawm aqueous yam tsis muaj kev sib koom ua ke.

Dab tsi Tsis Pab

Chlorhexidine.Combining CPC nrogtshuaj chlorhexidinetsis muaj cov txiaj ntsig antimicrobial thiab ua rau muaj kev pheej hmoo ntawm mucosal irritation. Ob qhov kev ua haujlwm tsom mus rau cov txheej txheem zoo sib xws, thiab lawv cov ntsiab lus tseem ceeb tsis ua kom tiav ib leeg. Yog tias koj xav tau chlorhexidine- qib kev ua tau zoo, siv chlorhexidine. Yog tias koj xav tau chlorhexidine- theem kam rau ua, siv CPC. Kev sib xyaw ua ke ua rau koj qhov phem tshaj plaws ntawm ob qho tib si.

Anionic polymers rau tartar tswj. Pyrophosphatesthiabpolyphosphatesyog cov tshuaj tiv thaiv- cov tshuaj tartar thiab cov chelators muaj zog. Lawv tuaj yeem khi CPC thiab txo nws qhov muaj. Yog hais tias cov tshuaj tiv thaiv -tartar thiab tshuaj tiv thaiv kab mob yog ob qho tib si yuav tsum tau, sim ua tib zoo soj ntsuam kev sib xyaw ua ke. Cov tshuaj tiv thaiv - tus neeg sawv cev tartar yuav tau noj cov tshuaj tua kab mob.

Cov qib ethanol siab. Ethanolyog qee zaum siv los solubilize tsw roj los yog ntxiv rau "kho" cov nyhuv sensory. CPC yog soluble nyob rau hauv ethanol, tab sis siab ethanol concentrations yuav ua rau lub qhov ncauj mucosa thiab tsis txhim kho CPC kev ua tau zoo. Yog tias siv ethanol, khaws cia hauv qab ntawm qib uas ua rau mob stinging, thiab xyuas kom meej tias CPC tseem nyob hauv cov tshuaj tom qab ethanol tau evaporated los ntawm qhov ncauj kab noj hniav.

Siv Qib los ntawm Hom Khoom

Lub qhov ncauj. 0.05-0.1% CPCyog tus qauv. Clinical trials ntawm0.045–0.065%tau ua kom pom kev txo cov plaque hauv cov25-35%.nrog tsawg staining los yog saj cuam tshuam. Hauv Suav teb, txoj cai txwv rau kev ntxuav qhov ncauj yog0.05%. Rau kev lag luam xa tawm, lees paub qhov txwv hauv zos ua ntej ua tiav cov qauv.

Tshuaj txhuam hniav. 0.1-0.5% CPC, nrog rau tus nqi tiag tiag ntawm dawb (tsis muaj kev cuam tshuam) CPC yog tus lej uas tseem ceeb. Yog hais tias cov mis muaj SLS los yog anionic thickeners, cov ntawv sau lo ntsiab muag overstates qhov zoo concentration.

Lozenges thiab caj pas tshuaj tsuag.Feem ntau1.5 mg CPC ib unit. Cov qauv xa tawm txwv lub sijhawm nyob, yog li qhov kev sib tw formulation yog txawv: tswj CPC muaj nyob rau hauv cov khoom siv los yog cov tshuaj txau tsis yog cov tshuaj aqueous.

Cov tshuaj ntxuav tes thiab tu tawv nqaij.Mus txog0.2% CPC. Cov formulations no feem ntau zam SLS rau ntawm daim tawv nqaij compatibility vim li cas, uas tshwm sim ua rau CPC compatibility yooj yim dua.

Txoj Cai Sequencing uas zam feem ntau teeb meem

Thaum txhim kho CPC- raws li cov khoom siv kho qhov ncauj, qhov kev txiav txim uas koj kaw qhov kev txiav txim siab txiav txim siab seb koj puas yuav muaj teeb meem kev sib raug zoo.

• Xauv lub tshuab surfactant ua ntej.Yog hais tias tus surfactant yog anionic, tsis muaj tus nqi ntawm pH tuning los yog CPC concentration hloov yuav rov qab tau cov kev ua poob lawm. Xaiv tsis yog -ionic lossis amphoteric ua ntej koj sau lwm yam rau hauv cov qauv.
• Xauv lub thickener thib ob.Ua kom cov thickener them rau surfactant system. Tsis yog - ionic thickeners yog lub neej ntawd kev nyab xeeb.
• Xauv lub abrasive thib peb.Silica nrog qis CPC binding, los yog qib silica tshwj xeeb kuaj rau CPC compatibility.
• Xauv pH plaub.Hom phiajpH 6.0-6.5. Tsis pub nrog citrate lossis phosphate. Tsis txhob muaj ntau cov kua qaub.
• Ntxiv CPC kawg,ua ntej- yaj nyob rau hauv ib qho me me ntawm cov dej purified. Ntxiv CPC lig hauv cov txheej txheem sib xyaw ua kom txo qis hauv zos khi rau cov thickeners lossis abrasives ua ntej lawv muaj dej txaus.

Cov kab ke no tsis yog kev lees paub rau txhua qhov kev sib cuam tshuam, tab sis nws tshem tawm cov hom kev ua tsis tiav feem ntau. Retrofitting compatibility rau hauv cov mis uas twb muaj SLS yog kim thiab tsis tshua muaj kev vam meej.

Dab tsi los nug tus neeg muag khoom

Yog tias koj tab tom nrhiav CPC los ntawm Tuam Tshoj chaw tsim khoom, cov lus nug txog kev lag luam tsis yog hais txog nqe lossis ntim khoom. Lawv yog hais txog cov ntaub ntawv batch.

Nug raukev ntsuam xyuas los ntawm HPLC, tsis yog ib thaj tsam. Nug raudej cov ntsiab lus. CPC monohydrate muaj cov ntsiab lus dej theoretical nyob ib puag ncig5.3%. Anhydrous CPC yuav nyeem qis dua. Daim ntawv tseem ceeb rau solubility thiab stability. Nug rauresidue ntawm ignitionthiabcov hlau hnyav. Ph.Eur. txwv rau cov hlau hnyav yog20 ppm. Nug seb cov khoom puas tau raug sim rau kev sib raug zoo nrog cov khoom siv hauv lub qhov ncauj ntau - tsis yog txhua tus neeg muag khoom yuav muaj cov ntaub ntawv no, tab sis cov uas ua yog cov uas nkag siab txog cov khoom.

COA yuav tsum suav nrog qhov ntsuas qhov tseeb, tsis yog qhov tshwj xeeb. COA uas hais tias "Ntau dua lossis sib npaug rau 99%" tsis muaj tus lej yog tus qauv, tsis yog cov ntaub ntawv teev tseg.

Sourcing CPC los ntawm Alfa Chemical

Alfa Chemical khoomCetylpyridinium Chloride (CAS 123-03-5)los ntawm Zhengzhou, Tuam Tshoj, raws li ib tug dawb crystalline hmoov nrogNtau dua lossis sib npaug li 99% kev soj ntsuam los ntawm HPLC. Txhua batch nkoj nrog batch - tshwj xeeb COA thiab SDS. Muaj feem cuam tshuam cov organic intermediates muaj npe hauv qabOrganic Chemistry. Rau cov lus nug los yog qauv thov,tiv tauj peb pab neeg technical.